

| Dosage | Package | Price per Dose | Price | |
|---|---|---|---|---|
| 25mg | 360 pill | CAD0.99 | CAD421.82 CAD358.55 Best Price Popular | |
| 25mg | 180 pill | CAD1.15 | CAD243.00 CAD206.55 | |
| 25mg | 120 pill | CAD1.34 | CAD190.26 CAD161.73 | |
| 25mg | 90 pill | CAD1.48 | CAD155.88 CAD132.49 | |
| 25mg | 60 pill | CAD1.62 | CAD114.61 CAD97.42 | |
| 25mg | 30 pill | CAD2.34 | CAD82.51 CAD70.13 | |
| 50mg | 90 pill | CAD2.03 | CAD215.48 CAD183.16 | |
| 50mg | 60 pill | CAD2.22 | CAD155.88 CAD132.49 | |
| 50mg | 30 pill | CAD2.92 | CAD103.15 CAD87.67 | |
| 75mg | 180 pill | CAD1.95 | CAD412.65 CAD350.75 | |
| 75mg | 120 pill | CAD2.34 | CAD330.11 CAD280.60 | |
| 75mg | 90 pill | CAD2.46 | CAD259.04 CAD220.19 | |
| 75mg | 60 pill | CAD2.53 | CAD178.80 CAD151.98 | |
| 75mg | 30 pill | CAD3.25 | CAD114.61 CAD97.42 |
Imipramine is a tricyclic antidepressant. This review describes its main uses, how it works, and what patients commonly experience during treatment. It is used to treat major depressive disorder and certain other mood disorders. It works by altering the balance of natural chemicals in the brain, mainly norepinephrine and serotonin. This can help restore mood and relieve symptoms such as sadness, sleep problems, and low energy. The medication is available by prescription and should be used under medical guidance.
Imipramine blocks the reabsorption of norepinephrine and serotonin in nerve cells, which increases their levels in brain circuits that regulate mood and stress responses. Its effects may take several weeks to become evident. Because it also has anticholinergic properties, it can affect the nervous system in multiple ways, including heart rate and digestion. This combination helps rebalance mood but can raise the risk of certain side effects for some people.
The primary use is moderate to severe depression. It can also be prescribed for panic disorder and some anxiety conditions, and in some cases nighttime enuresis in children, though this use is less common today. Doctors personalize treatment to each patient, considering medical history, other medicines, and the potential benefits and risks. Your clinician will decide if imipramine is appropriate for you.
Take imipramine exactly as prescribed. It is usually taken once or multiple times per day with or without food, depending on your schedule. Do not stop suddenly, which can cause withdrawal symptoms. Do not exceed the prescribed dose. Regular follow-up visits help adjust the dose safely and monitor heart rhythm and mood changes. Swallow tablets whole with a full glass of water.
Imipramine can improve mood, sleep, and energy levels over the weeks. In patient reviews, many report gradual mood lift and better daytime function after a few weeks, with sleep improving as anxiety recedes. Relief varies; it may take 2 to 6 weeks to feel noticeable benefits. If there is no improvement after several weeks, a clinician may adjust the treatment plan.
Common effects include drowsiness, dry mouth, constipation, blurred vision, weight gain, and dizziness. Some people feel urinary retention or a feeling of being slowed down. These symptoms often lessen with time or dose adjustments. Drinking fluids, chewing sugarless gum for dry mouth, and avoiding activities requiring alertness if sedated can help manage them.
Serious heart rhythm problems can occur, especially in older adults or at high doses. Do not combine with monoamine oxidase inhibitors or certain other antidepressants without medical supervision. Alcohol can worsen drowsiness and impair coordination. Inform your doctor about all medicines, including over-the-counter and herbal products, to prevent dangerous interactions. Seek urgent care if chest pain, fainting, or severe allergic reactions occur.
People with a history of heart disease, glaucoma, seizures, or prostate enlargement require careful evaluation. Pregnant or breastfeeding individuals should discuss risks with their provider. Older adults may be more sensitive to side effects, especially dizziness and heart issues. If you have thoughts of self-harm, sudden mood changes, or unusual bleeding, contact a clinician promptly.
Store at room temperature, away from light and moisture. Keep out of reach of children and pets. Do not use outdated pills. If you miss a dose, do not double up unless advised by a clinician. Proper disposal guidelines help prevent accidental ingestion by others and protect the environment.
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