

| Dosage | Package | Price per Dose | Price | |
|---|---|---|---|---|
| 25mg | 360 pill | CAD0.99 | CAD421.82 CAD358.55 Best Price Popular | |
| 25mg | 180 pill | CAD1.15 | CAD243.00 CAD206.55 | |
| 25mg | 120 pill | CAD1.34 | CAD190.26 CAD161.73 | |
| 25mg | 90 pill | CAD1.48 | CAD155.88 CAD132.49 | |
| 25mg | 60 pill | CAD1.62 | CAD114.61 CAD97.42 | |
| 25mg | 30 pill | CAD2.34 | CAD82.51 CAD70.13 | |
| 50mg | 90 pill | CAD2.03 | CAD215.48 CAD183.16 | |
| 50mg | 60 pill | CAD2.22 | CAD155.88 CAD132.49 | |
| 50mg | 30 pill | CAD2.92 | CAD103.15 CAD87.67 | |
| 75mg | 180 pill | CAD1.95 | CAD412.65 CAD350.75 | |
| 75mg | 120 pill | CAD2.34 | CAD330.11 CAD280.60 | |
| 75mg | 90 pill | CAD2.46 | CAD259.04 CAD220.19 | |
| 75mg | 60 pill | CAD2.53 | CAD178.80 CAD151.98 | |
| 75mg | 30 pill | CAD3.25 | CAD114.61 CAD97.42 |
Disclaimer: This information is for general educational purposes and does not replace professional medical advice. Always consult your healthcare provider or pharmacist before starting any medication.
Tofranil is the brand name for imipramine, a type of antidepressant called a tricyclic antidepressant (TCA). In Canada, imipramine is a prescription medicine that may be available as the brand Tofranil or as a generic imipramine product. The medicine is taken by mouth and works by helping to balance certain chemicals in the brain that affect mood and emotions.
Imipramine has been used for several decades to treat symptoms of depression and may be prescribed for other conditions as determined by a clinician. It is not a fast-acting pain reliever, sleeping aid, or stimulant, and it requires careful supervision by a healthcare professional. Brand names and formulations can vary, and the exact product you receive should be confirmed with your pharmacist.
The decision to start Tofranil should be made with a healthcare professional who can review your medical history, current medications, and potential risks. If you have questions about why this medicine has been prescribed for you, ask your clinician or pharmacist for clarification. Do not use Tofranil if you are not under medical supervision.
Tofranil may require a prescription depending on local rules. Your pharmacist can confirm whether a prescription is needed in your area and provide additional product information for your situation.
The most common reason a doctor may prescribe imipramine is to help manage symptoms of depression. It can also be used for certain anxiety-related conditions or other indications as determined by a clinician. The specific problems being treated, along with your response to therapy, guide how long the medicine is used.
Medical professionals consider several factors when deciding on imipramine therapy, including your medical history, any other medications you take, and your tolerance for side effects. Because responses to antidepressants vary, some people may begin to notice gradual improvement after weeks of daily use, while others may need a longer period of treatment under supervision.
Imipramine is not intended for use in everyone. If your doctor decides that another medicine is more appropriate for your condition, they may adjust your treatment plan accordingly. If your symptoms worsen or you experience new or worsening side effects, contact your clinician promptly.
Your pharmacist can help explain how imipramine fits with your overall treatment plan and can discuss potential alternatives if this medicine is not suitable for you. Do not change or stop your treatment without medical advice.
Tofranil belongs to the class of drugs called tricyclic antidepressants. It works by changing the balance of certain natural substances in the brain, particularly norepinephrine and serotonin. This adjustment can help improve mood, sleep, energy levels, and overall emotional well-being for many people.
The exact mechanism and the time to see benefit can vary from person to person. Imipramine may take several weeks of regular use before noticeable improvements occur. The medicine also has other effects on the brain and nervous system that can influence side effects, both mild and more significant.
The information provided here is general. For details about how imipramine may affect you personally, consult your clinician or pharmacist. Your healthcare professional will monitor your response and may adjust the treatment plan as needed.
Because every patient differs, it is important to follow the prescribed plan and report any new or unusual symptoms to your healthcare team promptly. They can help determine whether imipramine is the right option for you or if a different approach is better suited to your needs.
Take Tofranil exactly as prescribed by your doctor. Do not change the dose or frequency without consulting a clinician. The tablet is meant to be swallowed with a drink of water, and it should be taken at roughly the same time each day to help maintain steady levels in your body.
You may be advised to take Tofranil with or without food depending on your tolerance and the product you receive. Avoid alcohol while using this medicine, as it can increase side effects such as drowsiness or dizziness and may affect how well the medicine works.
Storage should be in a cool, dry place away from light and out of reach of children. Do not share your medication with others, even if they have similar symptoms. If you need to dispose of unused tablets, ask your pharmacist how to do so safely.
If you miss a dose, take it as soon as you remember unless it is almost time for your next dose. In that case, skip the missed dose and resume your regular schedule. Do not take two doses at once to make up for a missed dose. If you are uncertain what to do after missing a dose, contact your clinician or pharmacist for guidance.
Do not stop taking Tofranil abruptly without medical advice. Stopping suddenly can cause withdrawal symptoms or a return of symptoms. Your doctor will guide a gradual reduction if stopping is appropriate for you.
Your doctor may periodically review your need for continued therapy and may adjust the duration of treatment based on your response and any side effects you experience. Always bring a current list of all medicines you take to appointments so your clinician can assess potential interactions.
Imipramine should not be used by people who have a known allergy to imipramine or other tricyclic antidepressants. An allergic reaction can include symptoms such as hives, swelling, or trouble breathing. If you have had a severe reaction to similar medicines in the past, tell your clinician before starting Tofranil.
People with certain heart conditions, such as recent heart attack, irregular heartbeat, or significant heart rhythm problems, may be advised against using imipramine. Your doctor will determine safety based on your heart health and other risk factors.
Imipramine may worsen certain mental health conditions, including a history of mania or hypomania. If you notice unusually elevated mood, increased activity, or rapid changes in thinking, contact your healthcare provider promptly.
Glaucoma, urinary retention, severe liver or kidney disease, seizures, or a risk of seizures may influence whether imipramine is appropriate for you. Discuss all these conditions with your clinician so they can assess potential risks and determine the safest treatment approach.
Do not start imipramine if you are taking or have recently taken a monoamine oxidase inhibitor (MAOI) or certain other strong antidepressants. A clinician will provide specific instructions about when it is safe to start imipramine after stopping these medicines. If you are pregnant, planning to become pregnant, or breastfeeding, speak with your provider about potential risks and alternatives.
Like many medicines, imipramine can cause side effects or interact with other drugs. A clinician will weigh the benefits against possible risks for you, and they will monitor you for adverse effects during treatment. If you notice warning signs such as chest pain, severe headache, fainting, or severe allergic reactions, seek urgent medical help.
Tell your doctor about all medicines you take, including over-the-counter products and herbal supplements. Some substances can interact in unpredictable ways with imipramine and may raise the risk of serious effects. Your pharmacist can help you review potential interactions before starting this medicine.
Imipramine can affect heart rhythm and blood pressure in some people. It may also cause drowsiness or dizziness, which can increase the risk of falls or accidents. Avoid driving if you feel impaired, and do not operate heavy machinery until you know how the medicine affects you.
There is a potential risk of persistent mood changes or suicidality in younger people starting antidepressants. If you or a loved one notices new or worsening thoughts of harming oneself, contact a healthcare professional promptly or seek urgent care if there is immediate danger.
Many people tolerate imipramine well, but side effects can occur. Common effects include drowsiness or sleepiness, dry mouth, constipation, blurred vision, and a feeling of dizziness or lightheadedness when standing up quickly. Some people notice weight changes or mild stomach upset.
Other possible effects include increased heart rate, sweating, or changes in appetite. Sexual side effects, such as reduced sexual desire or difficulty reaching orgasm, may occur for some individuals. These effects are usually more noticeable in the first weeks of treatment and may lessen over time for some patients.
Less common but more serious symptoms to watch for include severe chest pain, fainting, severe headaches, seizures, confusion, or signs of an allergic reaction such as swelling of the face or throat, severe rash, or trouble breathing. If you experience any of these, seek immediate medical attention.
Your clinician will explain which side effects are most likely for you and will offer guidance on how to manage them. If side effects are troublesome or do not go away, do not stop the medication on your own—talk with your doctor about possible adjustments to your regimen.
Imipramine can interact with many other medicines. Some interactions may increase the risk of serious side effects, while others can make the medicine less effective. Always tell your pharmacist about all medicines you take, including prescription drugs, non-prescription products, and herbal supplements.
Important interactions to discuss with your clinician include monoamine oxidase inhibitors (MAOIs) or other antidepressant medications, which can raise the risk of serious effects if used together or if used too close in time. Other antidepressants, anticholinergic drugs, certain heart medications, and medicines that affect the electrical activity of the heart can also interact with imipramine.
Alcohol can amplify certain side effects such as drowsiness and dizziness, and it may worsen the overall safety profile when combined with imipramine. Your clinician may advise avoiding or limiting alcohol while taking this medicine.
If you start a new prescription or an over-the-counter product, inform your pharmacist before using it with imipramine. Do not start or stop any medicine without professional guidance to minimize risk of interactions.
Pregnant or planning pregnancy individuals should discuss the potential benefits and risks of imipramine therapy with a clinician. The medicine may affect fetal development or newborn health, depending on dosage, duration, and other factors. Your doctor will consider these elements when deciding whether imipramine is appropriate during pregnancy.
Breastfeeding while taking imipramine requires careful consideration. The medication can pass into breast milk and may affect an infant. If you are breastfeeding or plan to nurse, talk with your healthcare provider about the potential risks and options.
If you are of reproductive age, share your plans with your clinician. They can help weigh the risks and offer alternatives if needed. Do not start or stop this medicine based on assumptions about pregnancy without medical advice.
For any pregnancy-related questions or concerns, rely on the official patient leaflet and your healthcare team for personalized guidance rather than statements found in general information.
Below are common questions people have when starting or using imipramine. Answers are general guidelines and should not replace advice from your clinician. If you have specific concerns, contact your pharmacist or doctor.
Because this section contains multiple questions, if you need more detail about any item, ask your healthcare provider for additional information tailored to your situation.
Remember to bring a current list of all your medications to appointments so your clinician can review potential interactions and adjust your treatment as needed.
If you experience any serious or concerning symptoms, seek medical help promptly rather than waiting for a routine check-up.
Many people begin to notice gradual improvements over several weeks of regular use. The full benefit may take longer and depends on your specific condition and how you respond to the medicine. Do not expect immediate relief after the first dose.
If you miss a dose, take it as soon as you remember unless it is almost time for your next dose. If it is near the time for the next dose, skip the missed dose and resume your normal schedule. Do not take two doses at once to catch up.
Always tell your doctor about all medicines you take, including over-the-counter products and supplements. Some combinations can cause serious side effects or reduce effectiveness. Do not start new medicines without clearing them with your clinician or pharmacist.
Avoid or limit alcohol while using this medicine. Alcohol can intensify dizziness, drowsiness, and other side effects, and may affect how well the medicine works for you.
Feeling sleepy or dizzy can happen, especially when starting treatment or changing the dose. If these effects interfere with daily activities, contact your clinician. They may adjust the dose or suggest ways to manage these symptoms.
Some people may notice changes in weight or sexual function while taking imipramine. If these effects are bothersome or persistent, discuss them with your clinician. They can evaluate alternatives or provide strategies to help manage symptoms.
Because drowsiness and dizziness can occur, you should assess how the medicine affects you before driving or performing tasks that require alertness. If you feel less alert, avoid driving until you know how you respond.
If an overdose is suspected, seek urgent medical help immediately. Symptoms can include confusion, extreme drowsiness, fast or irregular heartbeat, seizures, or fainting. Do not wait to seek help if you think you have taken too much medication.
Doctors may continue antidepressant therapy for a period after improvement to prevent relapse. The decision about continuing or stopping treatment is individualized and should be guided by your clinician. Do not stop suddenly without medical advice.
Store imipramine in a place that children cannot access, away from heat and moisture. Keep the bottle tightly closed when not in use. If you no longer need the medicine, ask your pharmacist about safe disposal options.
Official patient information and product leaflets provided with your medication explain how to use imipramine safely. Your local pharmacist can also provide guidance tailored to your region and product form.
Health Canada and provincial medical authorities publish drug information that can help you understand the risks and benefits of this medicine in Canada. If you have questions about eligibility, coverage, or prescription status, consult a healthcare professional or your pharmacist.
For personalized answers, talk with your doctor, nurse, or pharmacist. They can review your medical history, other medicines you take, and any health concerns you have to ensure imipramine is appropriate for your situation.
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