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| 10 pills | C$2.89 | C$41.30 C$28.91 |
Trimethoprim is an antibiotic in the antifolate class. It blocks a bacterial enzyme needed to make DNA, and it is primarily used to treat urinary tract infections.
You take Trimethoprim by mouth as tablets or a liquid. The usual course lasts a few days to a week, as prescribed. It treats infections caused by bacteria that are sensitive to the medicine. Your doctor may prescribe it alone or with another medicine, depending on the infection.
The primary use is to treat urinary tract infections, including cystitis and some kidney infections. It helps relieve symptoms such as burning when you urinate and frequent urge to go. It is most effective when started early in the infection and taken as directed.
Secondary indications include other infections caused by susceptible bacteria. This can include certain gynecologic infections, some prostatitis cases, and some skin or soft tissue infections. In many situations, Trimethoprim is given together with sulfamethoxazole to broaden the range of bacteria it can treat. Your clinician will decide if the combination is right for your illness.
Trimethoprim slows bacterial growth by blocking dihydrofolate reductase, an enzyme bacteria use to make folic acid and build DNA. Without enough DNA, bacteria cannot multiply well. Humans get folate from food, so our cells are less affected. This makes the medicine effective against bacteria while being gentler on you.
Because of this mechanism, Trimethoprim is usually described as bacteriostaticโmeaning it stops bacteria from growing rather than instantly killing them. When used with sulfamethoxazole, the combination can be bactericidal, meaning it can kill certain bacteria more effectively.
Common side effects include nausea, vomiting, loss of appetite, and diarrhea. A skin rash can occur, and some people feel faint or dizzy. If you notice swelling, trouble breathing, or a severe skin reaction, seek medical help right away.
Less common but important issues include changes in blood counts, liver or kidney problems, and severe allergic reactions. Trimethoprim can interact with other medicines, such as blood thinners or methotrexate, so share your current drugs with your clinician. Pregnancy and breastfeeding require medical advice, as safety can vary by situation. Protect your skin from strong sunlight, as light sensitivity can occur. Always complete the full course as prescribed unless your clinician tells you otherwise.
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